@article{102160,
  keywords = {Genomics},
  author = {Kwaga JKP and Tizhe DT and Ogra IO and Apollos SD},
  title = {Potentials of genomics in combating neglected tropical diseases (NDTs) in Africa: a brief review},
  abstract = {<p>Neglected tropical diseases (NTDs) represent a significant global health challenge, affecting over one billion individuals, predominantly in impoverished tropical and sub-tropical regions of the world. These diseases contribute to a cycle of poverty, ill-health, and social exclusion. In recent years, the emergence and integration of genomic technologies into public health research has offered new opportunities for understanding the dynamics of NTDs in terms of transmission, infection, and resistance mechanisms, which in turn pave ways for monitoring the pathogens evolution, diagnostics and control strategies that are precise and cost-effective. This review examines the genomic studies, epidemiology, burden, and socio-economic impacts of NTDs, particularly within the African context. It underscores the historical neglect of these diseases in public health agendas and highlights the pressing need for enhanced funding, innovative research, and collaborative policies to combat their prevalence. It emphasizes the pivotal role of genomics in advancing disease surveillance, outbreak management, and the development of novel diagnostics, therapeutics, and preventive strategies. By leveraging advancements in genomic technologies, including whole-genome sequencing and CRISPR-based diagnostics. The review aims to inform targeted interventions and foster a one health approach that integrates human, animal, and environmental health. Furthermore, this analysis explores the potential of genomics in addressing the unique challenges posed by NTDs, ultimately contributing to the global targets set by the WHO for the elimination of these diseases by 2030. The findings underscore the urgent need for a multidisciplinary approach to effectively tackle NTDs and pave the way for substantial improvements in public health outcomes across Africa and beyond</p>
},
  year = {2025},
  journal = {EUREKA: Life Sciences},
  pages = {54-61},
  publisher = {OU Scientific Route},
  issn = {2504-5695, 2504-5687},
  doi = {10.21303/2504-5695.2025.003774},
  language = {eng},
}