@article{103016,
  keywords = {Alpha-gal, Anaphylaxis, Antivenom, envenomation, Snake, snakebite},
  author = {Dart R},
  title = {Snake Antivenom Reactions: A New Finding and Continued Controversy.},
  abstract = {<p>The role of snake antivenom in the management of venomous snakebite has been debated for decades. In this issue of&nbsp;<em>Annals</em>, Filip et al<a aria-label="Reference 1" href="https://www.annemergmed.com/article/S0196-0644(25)01237-5/abstract#"><sup>1</sup></a>&nbsp;reveal a new finding that clarifies our understanding of acute antivenom reactions and may change our use of snake antivenoms. Before 2001, the only product available in the United States was Antivenom Crotalidae Polyvalent (Wyeth). Introduced in the 1950s, the Wyeth antivenom was effective but caused acute and delayed (serum sickness) reactions. The product occasionally triggered life-threatening anaphylaxis, which caused many clinicians to avoid its use.<a aria-label="Reference 2" href="https://www.annemergmed.com/article/S0196-0644(25)01237-5/abstract#"><sup>2</sup></a>&nbsp;It was voluntarily withdrawn by the manufacturer following the introduction of a safer product.</p>
},
  year = {2025},
  journal = {Annals of emergency medicine},
  month = {10/2025},
  issn = {1097-6760},
  doi = {10.1016/j.annemergmed.2025.09.023},
  language = {eng},
}