@article{103976,
  keywords = {Survival Analysis, Treatment,  Leishmania (Viannia) braziliensis, disseminated leishmaniasis},
  author = {Leal JFDC and Bezerra Silva CC and Nascimento MBS and Gonçalves RT and Fernandes LHG and Campos ASC and Araújo FMD and Sampaio RNR and Barroso DH},
  title = {Survival Analysis in Cutaneous Leishmaniasis Patients: A Retrospective Cohort Study},
  abstract = {<p><strong>Background/Objectives:</strong></p>

<p>American Tegumentary leishmaniasis typically presents as a single ulcerative lesion, but atypical clinical forms exist with diverse physiopathology and treatment responses. Disseminated cutaneous leishmaniasis is a less common presentation that is often challenging to treat and for which evidence-based clinical decisions are scant. A better understanding of treatment response may support the development of alternative therapeutic strategies. This study reports a retrospective cohort analysis using a time-to-event outcome to compare disseminated leishmaniasis with localized cutaneous leishmaniasis using a multivariate model.</p>

<p><strong>Methods:</strong></p>

<p>A total of 366 patients were screened for inclusion between 2014 and 2024, of whom 123 met the inclusion criteria.</p>

<p><strong>Results:</strong></p>

<p>After adjustment for age and sex, patients with disseminated cutaneous leishmaniasis had a significantly longer time to healing than those with localized cutaneous leishmaniasis (HR = 0.29; p = 0.021).</p>

<p><strong>Conclusions:</strong></p>

<p>Disseminated cutaneous leishmaniasis seems to be an important predictor of poorer clinical outcomes with prolonged healing time. New therapeutic strategies are urgently needed to address this issue.</p>
},
  year = {2026},
  journal = {Biomedicines},
  volume = {14},
  pages = {1 - 9},
  month = {08/2026},
  publisher = {MDPI AG},
  issn = {2227-9059},
  url = {https://www.mdpi.com/2227-9059/14/8/1762/pdf?version=1785918265},
  doi = {10.3390/biomedicines14081762},
  language = {ENG},
}