@article{18338,
  keywords = {Acute disease, Adolescent, Adult, Aged, Angiotensin-Converting Enzyme Inhibitors, Chronic Disease, Enteritis, Enzyme Inhibitors, Female, Granuloma, Hodgkin Disease, Humans, leprosy, Liver Cirrhosis, Biliary, Liver Diseases, Male, Middle Aged, Peptidyl-Dipeptidase A, Prednisolone, Sarcoidosis, schistosomiasis, Tuberculosis, Pulmonary},
  author = {Studdy P and Bird R and JAMES D G},
  title = {Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders.},
  abstract = {<p>Serum angiotensin-converting enzyme (SACE) activity was significantly higher in 90 patients with sarcoidosis (55 +/- [S.D.] 23 nmol min-1 ml-1) than in 80 healthy controls (34 +/- 9 nmol min-1 ml-1). Steroid therapy modified SACE activity; 60 sarcoidosis patients who were not being treated with steroids had significantly higher enzyme activities (58 +/- 24 nmol min-1 ml-1) than 30 steroid-treated sarcoidosis patients (40 +/- 19 nmol min-1 ml-1). In 50% of the non-steroid treated sarcoidosis patients SACE activity was more than 2 S.D. above the mean value for the controls. SACE activity was measured in 22 tuberculous patients (38 +/- 14 nmol min-1 ml-1), 20 leprosy patients (34 +/- 9 nmol min-1 ml-1), 31 with primary biliary cirrhosis (44 +/- 20 nmol min-1 ml-1), 26 with inflammatory bowel disease (31 +/- 9 nmol min-1 ml-1), 8 with hepatic granulomatous disease, 5 with Hodgkin's disease, and 2 with schistosomiasis. The combined false-positive rate for these non-sarcoidosis patients was 10%. Serial SACE assays provide useful information on the course of sarcoidosis and response to steroid treatment.</p>},
  year = {1978},
  journal = {Lancet (London, England)},
  volume = {2},
  pages = {1331-4},
  month = {1978 Dec 23-30},
  issn = {0140-6736},
  doi = {10.1016/s0140-6736(78)91972-4},
  language = {eng},
}