@article{25889,
  keywords = {Research, Poverty, Neglected tropical diseases (NTDs), Disease burden, DALY},
  author = {Philipsborn P and Steinbeis F and Bender M and Regmi S and Tinnemann P},
  title = {Poverty-related and neglected diseases - an economic and epidemiological analysis of poverty relatedness and neglect in research and development.},
  abstract = {<p><strong>BACKGROUND: </strong>Economic growth in low- and middle-income countries (LMIC) has raised interest in how disease burden patterns are related to economic development. Meanwhile, poverty-related diseases are considered to be neglected in terms of research and development (R&amp;D).</p>

<p><strong>OBJECTIVES: </strong>Developing intuitive and meaningful metrics to measure how different diseases are related to poverty and neglected in the current R&amp;D system.</p>

<p><strong>DESIGN: </strong>We measured how diseases are related to economic development with the income relation factor (IRF), defined by the ratio of disability-adjusted life-years (DALYs) per 100,000 inhabitants in LMIC versus that in high-income countries. We calculated the IRF for 291 diseases and injuries and 67 risk factors included in the Global Burden of Disease Study 2010. We measured neglect in R&amp;D with the neglect factor (NF), defined by the ratio of disease burden in DALYs (as percentage of the total global disease burden) and R&amp;D expenditure (as percentage of total global health-related R&amp;D expenditure) for 26 diseases.</p>

<p><strong>RESULTS: </strong>The disease burden varies considerably with the level of economic development, shown by the IRF (median: 1.38; interquartile range (IQR): 0.79-6.3). Comparison of IRFs from 1990 to 2010 highlights general patterns of the global epidemiological transition. The 26 poverty-related diseases included in our analysis of neglect in R&amp;D are responsible for 13.8% of the global disease burden, but receive only 1.34% of global health-related R&amp;D expenditure. Within this group, the NF varies considerably (median: 19; IQR: 6-52).</p>

<p><strong>CONCLUSIONS: </strong>The IRF is an intuitive and meaningful metric to highlight shifts in global disease burden patterns. A large shortfall exists in global R&amp;D spending for poverty-related and neglected diseases, with strong variations between diseases.</p>
},
  year = {2015},
  journal = {Global health action},
  volume = {8},
  pages = {25818},
  issn = {1654-9880},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306754/pdf/GHA-8-25818.pdf},
  doi = {10.3402/gha.v8.25818},
  language = {eng},
}