@article{26816,
  keywords = {Young Adult, Risk Factors, Middle Aged, Male, Humans, Geography, Female, Ethiopia, Elephantiasis, Aged, Adult},
  author = {Deribe K and Brooker S and Pullan R and Sime H and Gebretsadik A and Assefa A and Kebede A and Hailu A and Rebollo MP and Shafi O and Bockarie M and Aseffa A and Reithinger R and Cano J and Enquselassie F and Newport M and Davey G},
  title = {Epidemiology and individual, household and geographical risk factors of podoconiosis in Ethiopia: results from the first nationwide mapping.},
  abstract = {<p>Although podoconiosis is one of the major causes of tropical lymphoedema and is endemic in Ethiopia its epidemiology and risk factors are poorly understood. Individual-level data for 129,959 individuals from 1,315 communities in 659 woreda (districts) were collected for a nationwide integrated survey of lymphatic filariasis and podoconiosis. Blood samples were tested for circulating Wuchereria bancrofti antigen using immunochromatographic card tests. A clinical algorithm was used to reach a diagnosis of podoconiosis by excluding other potential causes of lymphoedema of the lower limb. Bayesian multilevel models were used to identify individual and environmental risk factors. Overall, 8,110 of 129,959 (6.2%, 95% confidence interval [CI] 6.1-6.4%) surveyed individuals were identified with lymphoedema of the lower limb, of whom 5,253 (4.0%, 95% CI 3.9-4.1%) were confirmed to be podoconiosis cases. In multivariable analysis, being female, older, unmarried, washing the feet less frequently than daily, and being semiskilled or unemployed were significantly associated with increased risk of podoconiosis. Attending formal education and living in a house with a covered floor were associated with decreased risk of podoconiosis. Podoconiosis exhibits marked geographical variation across Ethiopia, with variation in risk associated with variation in rainfall, enhanced vegetation index, and altitude.</p>
},
  year = {2015},
  journal = {The American journal of tropical medicine and hygiene},
  volume = {92},
  pages = {148-58},
  issn = {1476-1645},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288951/pdf/tropmed-92-148.pdf},
  doi = {10.4269/ajtmh.14-0446},
  language = {eng},
}