@article{28019, keywords = {Parasitic Diseases, Drug repositioning, Clinical use}, author = {Ferreira L and Andricopulo AD}, title = {Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective.}, abstract = {

Identifying new indications for clinically useful drugs is a worthwhile approach for neglected tropical diseases. The number of successful repurposing cases in the field is growing as not-for-profit organizations, in association with academia and pharmaceutical companies, enable screening campaigns for the identification of new repositioning candidates. Current programs have delivered encouraging results as the use of state-of-the-art technologies, such as genomic and structural biology tools, and high-throughput screening platforms have become increasingly common in infectious disease research. Drug repositioning has played a key part in improving the lives of those suffering from these conditions, as evidenced by successful precedents and recent studies on preeminent parasitic disorders.

}, year = {2016}, journal = {Drug discovery today}, volume = {21}, issn = {1878-5832}, doi = {10.1016/j.drudis.2016.06.021}, language = {eng}, }