@article{96949,
  keywords = {Virology, Infectious Diseases, Parasitology},
  author = {Griswold E and Eigege A and Adelamo S and Mancha B and Kenrick N and Sambo Y and Ajiji J and Zam G and Solomon J and Urude R and Kadimbo J and Danboyi J and Miri E and Nute AW and Rakers L and Nebe O and Anyaike C and Weiss P and Noland G and Richards F},
  title = {Impact of Three to Five Rounds of Mass Drug Administration on Schistosomiasis and Soil-Transmitted Helminths in School-Aged Children in North-Central Nigeria},
  abstract = {<p>Nasarawa and Plateau states of north-central Nigeria have implemented programs to control schistosomiasis (SCH) and soil-transmitted helminths (STH) in children since the 1990s. Statewide mapping surveys were conducted in 2013, when 11,332 school-aged children were sampled from 226 schools. The local government areas (LGAs) then received varying combinations of mass drug administration (MDA) for the next 5 years. We revisited 196 (87%) schools in 2018 plus an additional six (202 schools in total), sampling 9,660 children. We calculated overall prevalence and intensity of infection and evaluated associations with gender; age; behaviors; water, sanitation, and hygiene (WASH); and treatment regimen. Urine heme detection dipsticks were used for Schistosoma hematobium in both surveys, with egg counts added in 2018. Stool samples were examined by Kato-Katz for Ascaris lumbricoides, Trichuris trichiura, Schistosoma mansoni, and hookworm. Schistosomiasis prevalence among sampled students dropped from 12.9% (95% confidence interval [CI]: 11.1–14.9%) to 9.0% (95% CI: 7.5–10.9%), a statistically significant change (P &lt; 0.05). In 2018, eight LGAs still had &gt; 1% of children with heavy-intensity schistosome infections. Prevalence of STH infection did not significantly change, with 10.8% (95% CI: 9.36–12.5%) of children positive in 2013 and 9.4% (95% CI: 8.0–10.9%) in 2018 (P = 0.182). Heavy-intensity STH infections were found in &lt; 1% of children with hookworm, and none in children with A. lumbricoides or T. trichiura in either study. The WASH data were collected in 2018, indicating 43.6% of schools had a latrine and 14.4% had handwashing facilities. Although progress is evident, SCH remains a public health problem in Nasarawa and Plateau states.</p>
},
  year = {2022},
  journal = {The American Journal of Tropical Medicine and Hygiene},
  publisher = {American Society of Tropical Medicine and Hygiene},
  issn = {0002-9637, 1476-1645},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294711/pdf/tpmd211207.pdf},
  doi = {10.4269/ajtmh.21-1207},
  language = {eng},
}