@article{97588,
  keywords = {Infectious Diseases, Microbiology (medical), General Medicine},
  author = {Kositz C and Drammeh M and Vasileva H and Houghton J and Ashall J and D'Alessandro PU and Marks M and Bradley J},
  title = {Effects of Ivermectin Mass Drug Administration for Malaria Vector Control on Ectoparasites and Soil-Transmitted Helminths: A Cluster Randomised Trial},
  abstract = {<p>Ivermectin, used to control several neglected tropical diseases (NTDs), may also reduce malaria transmission. Mass drug administration (MDA) for malaria control therefore might have off-target impacts on NTDs.</p>

<h3>Methods</h3>

<p>In the Gambia, nested in a trial of ivermectin MDA, cross-sectional surveys measuring ectoparasites and soil-transmitted helminths (STH) in children aged 3 to 14 took place in June and November 2019, and in November 2021.</p>

<h3>Results</h3>

<p>Following MDA, scabies prevalence was 41.2% (237/576) in the control and 38.2% (182/476) in the intervention arm (OR 0.89 (95%CI 0 67 - 1 .2), p= 0.471) but by 2021 had rebounded to 38.8% (180/464) in the control and 53.2% (245/458) in the intervention arm. After MDA, prevalence of S. stercoralis was 16.8% (87/518) in the control and 9.1% (40/440) in the intervention arm (OR 0.4 (95%CI 0.16 – 0.94), p = 0.039). In 2021 it was 9.2% (38/413) in the control and 11.3% (45/399) in the intervention arm (OR 1.31 (95%CI 0.74 - 2.28), p = 0.35).</p>

<h3>Conclusion</h3>

<p>Scabies prevalence was similar between the two study arms. S. stercoralis prevalence was reduced. However, this effect did not last long: prevalence 2 years post MDA was similar between study arms.</p>
},
  year = {2022},
  journal = {International Journal of Infectious Diseases},
  publisher = {Elsevier BV},
  issn = {1201-9712},
  url = {https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2822%2900583-5},
  doi = {10.1016/j.ijid.2022.10.043},
  language = {eng},
}