@article{97900,
  author = {Igoe M and Casagrandi R and Gatto M and Hoover C. M. and Mari L and Ngonghala C. N. and Remais J. V. and Sanchirico J. N. and Sokolow S. H. and  Lenhart S. and de Leo G.},
  title = {Reframing Optimal Control Problems for Infectious Disease Management in Low-Income Countries},
  abstract = {<p>Optimal control theory can be a useful tool to identify the best strategies for the management of infectious diseases. In most of the applications to disease control with ordinary differential equations, the objective functional to be optimized is formulated in monetary terms as the sum of intervention costs and the cost associated with the burden of disease. We present alternate formulations that express epidemiological outcomes via health metrics and reframe the problem to include features such as budget constraints and epidemiological targets. These alternate formulations are illustrated with a compartmental cholera model. The alternate formulations permit us to better explore the sensitivity of the optimal control solutions to changes in available budget or the desired epidemiological target. We also discuss some limitations of comprehensive cost assessment in epidemiology</p>
},
  year = {2023},
  journal = {Bulletin of Mathematical Biology},
  volume = {85},
  pages = {1-31},
  publisher = {Springer Link},
  url = {https://link.springer.com/content/pdf/10.1007/s11538-023-01137-4.pdf?pdf=button},
  language = {Eng},
}