@article{98052,
  keywords = {Infectious Diseases, Public Health, Environmental and Occupational Health, General Medicine, Parasitology},
  author = {Rayment Gomez S and Maddren R and Liyew EF and Chernet M and Anjulo U and Tamiru A and Mengitsu B and Forbes K and Collyer B and Salasibew M and Anderson R},
  title = {Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia},
  abstract = {<p><strong>Background:</strong> Current WHO strategies for reaching soil-transmitted helminths (STH) elimination as a public health problem excludes treating certain adult populations in endemic areas, creating infection reservoirs that drive ‘bounce back’ of STH infection to pretreatment levels post-mass drug administration (MDA). Predisposition is a widespread, but poorly understood phenomena among helminth infections where individuals are predisposed to reinfection after repeated treatments.</p>

<p><strong>Methods:&nbsp;</strong>This analysis uses Geshiyaro project data, an STH control programme exploring transmission interruption by community-wide MDA and enhanced water, sanitation and hygiene during 2019–2023. Parasitological survey data from longitudinal cohorts are analysed using Kendall's Tau-b rank correlation to assess the evidence for predisposition to light or heavy infection between four consecutive rounds of MDA.</p>

<p><strong>Results:&nbsp;</strong>Correlation analyses revealed the strongest evidence for predisposition to heavy or light Ascaris lumbricoides infection was between survey 1 and 2 (Tau-b 0.29; p&lt;0.001). Overall patterns were not observed for Trichuris trichiura or hookworm infections, however, some significant and notable correlations were recorded for some stratifications and time points.</p>

<p><strong>Conclusions:&nbsp;</strong>Evidence for predisposition in endemic settings in southern Ethiopia with low STH prevalence suggests that more targeted approaches to MDA in those predisposed to infection may be a sensible control strategy if cheap, point of care diagnostics are available.</p>
},
  year = {2023},
  journal = {Transactions of The Royal Society of Tropical Medicine and Hygiene},
  pages = {1-8},
  publisher = {Oxford University Press (OUP)},
  issn = {0035-9203, 1878-3503},
  url = {https://academic.oup.com/trstmh/advance-article-pdf/doi/10.1093/trstmh/trad007/49564640/trad007.pdf},
  doi = {10.1093/trstmh/trad007},
  language = {Eng},
}