@article{98404,
  keywords = {Infectious Diseases, Public Health, Environmental and Occupational Health},
  author = {Muhi S and Osowicki J and O’Brien D and Johnson PDR and Pidot S and Doerflinger M and Marshall JL and Pellegrini M and McCarthy J and Stinear TP},
  editor = {Converse PJ},
  title = {A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain},
  abstract = {<p>Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host–pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.</p>
},
  year = {2023},
  journal = {PLOS Neglected Tropical Diseases},
  volume = {17},
  pages = {e0011394},
  publisher = {Public Library of Science (PLoS)},
  issn = {1935-2735},
  url = {https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011394&type=printable},
  doi = {10.1371/journal.pntd.0011394},
  language = {Eng},
}