01001nas a2200145   4500000000100000008004100001260001300042653002300055100001200078700001100090245003600101300001200137520068800149020001800837       2025                            d  bElsevier10apraziquantel (PZQ)1 aZhang F1 aYang Z00aAntiparasitic drug praziquantel  a509-5293 a<p>This chapter provides a detailed description of the antiparasitic drug praziquantel. It begins by reviewing the history of developing antischistosomal drugs, highlighting the remarkable efficacy of praziquantel in the treatment of schistosomiasis. Subsequently, it delves into the medicinal chemistry of praziquantel, discussing its structure-activity relationship, pharmacological differences between chiral isomers, deuterated praziquantel, and the solution of drug resistance. In the final section, the green synthesis of praziquantel and levorotatory praziquantel is discussed, along with the concept of green chemistry and process concerns in industrial drug synthesis.</p>
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