02062nas a2200469   4500000000100000008004100001260003700042100001300079700001100092700001200103700001400115700001400129700001300143700001900156700001500175700001200190700001500202700001300217700001100230700001500241700001500256700001200271700001500283700001300298700001300311700001300324700001000337700001600347700001500363700001800378700001500396700001500411700001400426700001400440700001300454245014800467856009900615300001300714490000700727520084400734022001401578       2025                            d  bPublic Library of Science (PLoS)1 aMitjà O1 aGass K1 aMarks M1 aCooper PJ1 aDiggle PJ1 aWaller L1 aAgana-Nsiire P1 aDofitas BL1 aDyson L1 aJacobson J1 aKaldor J1 aKim SH1 aVaz Nery S1 aRevankar C1 aSopoh G1 aSolomon AW1 aDagne DA1 aPathak P1 aYajima A1 aLin Z1 aBarogui MYT1 aScholte RC1 aSanikullah KH1 aDrakeley C1 aStresman G1 aGyapong J1 aAsiedu KB1 aPappas G00aGuidance for conducting and evaluating serological surveys to assess interruption of yaws transmission in the context of an eradication target  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012899&type=printable  ae00128990 v193 a<p>This document provides a summary of guidance developed for national programmes on conducting serosurveys to assess yaws transmission status, with the objective of confirming yaws seroprevalence below 1% at each of three serosurveys over a period of 3–10 years after reporting the last case of active yaws in a region. It proposes active testing of children aged 1–5 years through population-based surveys and includes recommendations on survey design, sample size determination, sampling&nbsp;of primary sampling units (PSUs) within an evaluation unit, sampling of households within PSUs, integration with existing public health surveys, and follow-up protocols for positive results. Geospatial analysis and sustained surveillance are recommended for accurate assessment of whether transmission interruption has been achieved.</p>
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