01647nas a2200205   4500000000100000008004100001260003400042653002400076653003900100653002200139653002700161653003200188100001500220700001600235700001500251245007000266856009000336520099000426022002501416       2025                            d  bOxford University Press (OUP)10aChromoblastomycosis10aNeglected tropical diseases (NTDs)10aCutaneous lesions10aTherapeutic challenges10aMelanised fungal infections1 aTuckwell W1 aYesudian PD1 aChandler D00aChromoblastomycosis: a contemporary review of a neglected disease  uhttps://academic.oup.com/ced/advance-article-abstract/doi/10.1093/ced/llaf201/81315793 a<p>Of the melanised fungal infections affecting humans, chromoblastomycosis (CBM) remains the most prevalent. Also known as chromomycosis, this condition typically manifests as insidious onset cutaneous lesions that eventually progress to cause physical disability. CBM is considered a Neglected Tropical Disease (NTD) by the World Health Organisation (WHO) due to its significant impact on impoverished populations throughout tropical regions, the paucity of research, and the opportunity to improve treatment and prevention. In many cases, the diagnosis is delayed; this is thought to be due to the multitude of clinical mimics and the lack of general awareness. Furthermore, the subcutaneous invasion of this infection creates therapeutic challenges. A small number of studies have identified partially successful treatments and potential pharmacological targets. Herein we present an updated review of this condition to give a contemporary perspective on a neglected disease.</p>
  a0307-6938, 1365-2230