02146nas a2200289 4500000000100000008004100001260001600042653001500058653001700073653001700090100001800107700001200125700001300137700001500150700003100165700001600196700001800212700001100230700001300241700001300254700001700267245007800284856009600362300000600458520137800464022001401842 2025 d bElsevier BV10aOne Health10aHuman health10aRedefinition1 aLefrançois T1 aAngot J1 aAutran B1 aBukachi SA1 aClaverie de Saint-Martin E1 aGiraudoux P1 aLefrançois E1 aLina B1 aOanh KTH1 aObura DO1 aDelfraissy J00aA new definition of human health is needed to better implement One Health uhttps://www.sciencedirect.com/sdfe/pdf/download/eid/1-s2.0-S0140673625010153/first-page-pdf a13 a

Since the COVID-19 pandemic, One Health approaches1 have revived attention to the interdependence of human, animal, and ecosystem health. However, human health is still predominantly viewed through the prism of disease affecting humans and related care activities, as illustrated by health expenditure and health regulation. This approach is now overly restrictive since interdependencies and holistic approaches are crucial for the prevention and preservation of human health, particularly in relation to interlinked climate, biodiversity, pollution, and health crises. We claim that redefining WHO's definition of human health will facilitate actual implementation of One Health approaches in the medical field, improve pandemic prevention, and reflect the many ways in which health determinants have evolved. Although the funding and very existence of WHO are under attack, with dramatic consequences on worldwide global health, WHO should seize the opportunity to change the definition of human health and thereby reinvent itself, showing its ability to evolve with the international context, base its recommendations and policies on updated science, and promote multilateralism and its values.

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