02174nas a2200301   4500000000100000008004100001260001000042653002000052653002800072653002200100653002600122653002200148100002800170700001300198700002200211700002700233700002500260700001400285700001500299700001600314700001500330700002300345700001800368245013600386856006300522520126200585022002501847       2025                            d  bWiley10aChagas' disease10aCell Adhesion Molecules10aOral Transmission10aAcute phase diagnosis10asVCAM-1 biomarker1 aVaitkevicius‐Antão V1 aSilva BA1 ada Silva Barros M1 ada Costa‐Oliveira CN1 ade Freitas Firmino L1 aSoares WA1 aMartins SM1 aCarrazone C1 aOliveira W1 ada Silva Rabelo MC1 ade Lorena VMB00aLongitudinal monitoring of cell adhesion molecules in acute Chagas disease patients and prognosis after treatment with benznidazole  uhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/tmi.141313 a<p>Chagas disease is a public health concern endemic to Brazil, with several cases of oral transmission. Detection of patients during the acute phase is rare due to mild, nonspecific symptoms and limitations in diagnostic testing. Some molecules, such as cell adhesion molecules (CAMs), have been highlighted as potential diagnostic and prognostic markers for diseases. The aim of this study was to evaluate CAMs in patients with acute Chagas disease who were treated with benznidazole. In 2019, patients from Pernambuco, in northeastern Brazil, were diagnosed with Trypanosoma cruzi infection. These patients were treated for 60 days and monitored for 2 years. sVCAM‐1, sP‐selectin, sL‐selectin, and sE‐selectin were quantified from the serum of patients using a flow cytometer. sVCAM‐1 showed significant potential to differentiate between negative and infected individuals before treatment (AUC = 0.875), with a positivity rate of 75%, like the gold standard (parasitological test) and higher than PCR tests. The sP‐selectin also yielded good results in monitoring thrombocytopenia and changes in coagulation after treatment. Therefore, we conclude that CAMs are potential biomarkers for Chagas disease during its primary phase.</p>
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