02379nas a2200373   4500000000100000008004100001260002000042653002800062653002500090653003000115653003000145653002500175100001500200700002200215700002000237700001500257700001200272700001600284700001400300700001400314700001600328700001300344700001300357700002600370700001400396700002300410700001900433700001400452700001300466245017500479856007900654490000700733520126500740       2025                            d  bOxford Academic10aChronic schistosomiasis10aImmunochromatography10aPoint-of-care diagnostics10aschistosomiasis screening10asub-Saharan migrants1 aHegazy AHA1 aPérez-Quílez  O1 aLópez-Muñoz I1 aChamorro A1 a Abad E1 aSan José A1 a Valera J1 aValerio L1 aSoldevila L1 aGorriz E1 aHerena D1 aFernández-Pedregal E1 aLlibre JM1 aFernández-Rivas G1 aJoan Cardona P1 aVallès X1 a Roure S00aPerformance (Sensitivity and Specificity) of a New Point-of-Care Immunochromatography to Screen for Imported Chronic Schistosomiasis Among Long-Term Sub-Saharan Migrants   uhttps://academic.oup.com/ofid/article/12/7/ofaf328/8196494#google_vignette0 v123 a<p><strong>Background</strong></p>

<p>Imported schistosomiasis is underdiagnosed among long-term migrants in non-endemic countries. Reference standard tests are lacking for the diagnosis of chronic schistosomiasis.</p>

<p><strong>Methods</strong></p>

<p>This study evaluated the sensitivity and specificity of a new immunochromatography (ICT) test using serum (s) or point-of-care finger-prick (FP) whole blood against standard serological tests in long-term migrants from sub-Saharan Africa.</p>

<p><strong>Results</strong></p>

<p>A total of 202 individuals were screened, with a mean age of 42.7 years. Of these, 75.7% were male, and 42.6% were from Senegal. Test positivity rates were 15.8% for ELISA, 24.3% for ICT-p, 46.5% for ICT-b (s), and 28.7% for ICT-b (FP). All tests showed good agreement with a clinical score but with heterogeneous agreement between them. Our results indicates a higher sensitivity for ICT-b (s). Positive responses after treatment suggest good specificity for all tests.</p>

<p><strong>Conclusions</strong></p>

<p>ICT-b (s) shows a higher sensitivity than the other standard tests. An ICT-b (FP) strategy could be used as a first-step point-of-care screening tool for probable chronic schistosomiasis.</p>