02683nas a2200421   4500000000100000008004100001260001200042653001300054653002000067653002100087653002300108100001500131700001500146700001400161700001400175700001300189700001500202700001600217700001700233700001500250700002000265700001700285700001400302700001400316700001700330700001400347700002500361700001300386700001800399700001800417700001500435700001600450245017100466856004500637490000700682520155800689022001402247       2025                            d  bMDPI AG10aExercise10aChronic Disease10aHealth behaviour10asedentary behavior1 aXavier IGG1 aAndrade PM1 aVitor RDL1 aBarros TC1 aSilva WT1 aPortela LF1 aHolanda MTD1 aSangenis LHC1 aSilva GMSD1 aMazzoli-Rocha F1 aMendes FDSNS1 aCosta ARD1 aVieira MC1 aAlmeida DPMD1 aValete CM1 aHasslocher-Moreno AM1 aCosta HS1 aParavidino VB1 aGonçalves TR1 aSaraiva RM1 aMediano MFF00aAssociation Between Physical Activity, Sedentary Time, and Quality of Life in Patients with Chagas Disease During COVID-19 Pandemic in Brazil: A Cross-Sectional Study  uhttps://www.mdpi.com/1660-4601/22/7/11370 v223 a<p><strong>Background: </strong>COVID-19 led to social isolation, potentially reducing physical activity (PA), increasing sedentary time, and lowering quality of life (QoL). This study investigated the association between these factors in patients with Chagas disease (ChD) during the pandemic.</p>

<p><strong>Methods:</strong> This cross-sectional study included 187 patients with ChD. PA and sedentary time were assessed by the IPAQ-short and QoL by the WHOQOL-Bref. The relationship between PA levels and sedentary time with QoL were assessed using unadjusted and adjusted generalized linear models.</p>

<p><strong>Results:</strong> The highest tertile of total PA was positively associated with the psychological (Exp β = 1.11; 95% CI: 1.02–1.22) and environmental (Exp β = 1.12; 95% CI: 1.01–1.23) QoL domains. The intermediate (Exp β = 1.12; 95% CI: 1.01–1.25) and highest (Exp β = 1.14; 95% CI: 1.02–1.27) tertiles of moderate-to-vigorous PA were positively associated with the physical domain. Similarly, both the intermediate (Exp β = 1.11; 95% CI: 1.01–1.22) and highest (Exp β = 1.12; 95% CI: 1.01–1.21) tertiles of moderate-to-vigorous PA were positively associated with the psychological domain. The highest tertile of sedentary time was associated with a decrease in the physical domain (Exp β = 0.88; 95% CI: 0.79–0.98).</p>

<p><strong>Conclusions:</strong> Higher levels of total and moderate-to-vigorous PA were associated with better QoL, while greater sedentary time was associated with poorer QoL.</p>
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