02731nas a2200361   4500000000100000008004100001260003700042653001800079653002000097653002700117100001500144700001600159700001500175700001700190700001800207700002600225700001700251700001500268700001300283700001800296700002400314700001400338700001700352700002500369700001400394700001600408700001300424245010500437856007800542490000700620520172800627022001402355       2025                            d  bPublic Library of Science (PLoS)10aFood security10aQuality of Life10achronic Chagas disease1 aCosta CJDN1 ada Silva PS1 aSaraiva RM1 aSangenis LHC1 ade Holanda MT1 aSperandio da Silva GM1 aMendes FDSNS1 aXavier IGG1 aCosta HS1 aGonçalves TR1 aRodrigues Junior LF1 aLamas CDC1 aHuguenin GVB1 aHasslocher-Moreno AM1 aKasal DAB1 aMediano MFF1 aMeira KC00aFood insecurity is associated with decreased quality of life in patients with chronic Chagas disease  uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.03284660 v203 a<jats:p>This study assessed the prevalence of food insecurity (FI) in patients with Chagas Disease (CD) and its association with anthropometric measurements, comorbidities, and quality of life (QoL). This cross-sectional study included CD patients of both sexes. The FI was evaluated using the Brazilian FI scale. Anthropometric measurements included weight, height, and waist circumference. Comorbidities included hypertension, diabetes, dyslipidemia, and obesity. Lipids and plasma glucose were collected. QoL was assessed using the Portuguese version of WHOQOL-Bref questionnaire. Linear and logistic regression models were fitted to evaluate the association between FI status and outcomes. From the 359 included participants (55.9% women, median age 62 years), 22.5% had mild, 5.6% moderate, and 2.5% had severe FI. In the adjusted models, mild FI was significantly associated with an increased odds of obesity (OR=1.83, 95%CI = 1.03 to 3.25). Moreover, significant associations were observed between FI and all QoL domains, including physical health (low FI: β = −8.43 95%CI −12.36 to −4.49; moderate/severe FI: β = −8.02 95%CI −14.11 to −1.94), psychological (low FI β = −5.54 95%CI −9.11 to −1.96; moderate/severe FI β = −7.22 95%CI −12.76 to −1.68), social relationship (low FI: β = −6.62 95%CI −10.37 to −2.88), environment (low FI: β = −8.79 95%CI −11.99 to −5.60; moderate/severe FI β = −13.56 95%CI −18.51 to −8.62), and overall (low FI β = −8.10 95%CI −12.15 to −4.06; moderate/severe FI: β = −16.82 95%CI −23.08 to −10.57). FI was consistently associated with poor QoL in patients with chronic CD.</jats:p>  a1932-6203