01636nas a2200241   4500000000100000008004100001260001200042653002000054653002600074653001800100653001100118653001600129653002400145100001200169700001100181700001600192700001200208700001300220700002200233245012200255520100300377022001401380       2025                            d  c08/202510aChagas' disease10aVector borne diseases10aLeishmaniasis10aDengue10aComorbidity10aMarginalised groups1 aMejia R1 aZhan B1 aUzcategui N1 aLopez A1 aCooper P1 aRomero-Sandoval N00aChagas and Vector-Borne Disease Exposures in an Indigenous Community in the Ecuadorian Amazon: A Retrospective Study.3 a<p>There are limited data on vector-borne diseases from the Ecuadorian Amazon, particularly among marginalized Indigenous populations. From a survey of Shuar communities in Ecuador, we measured IgG antibodies to Trypanosoma cruzi, dengue virus, and Leishmania spp. The prevalence of IgG antibodies was 7.4% for T. cruzi, 21.3% for dengue, and 96.8% for Leishmania spp. There was an increase in the risk of dengue infections with increasing age (per year; adjusted odds ratio [adj. OR]: 1.03, 95% CI: 1.01-1.05, P = 0.001) and among females (adj. OR: 2.17, 95% CI: 1.03-4.57, P = 0.041). There was an increase in T. cruzi anti-Tc24 IgG antibody levels with greater age (Spearman r = 0.553, P = 0.05). This study showed a high prevalence or exposure to Chagas disease, dengue, and Leishmania spp. There remains an unmet need for surveillance to monitor the transmission of Chagas and other vector-borne diseases and their associated morbidity in marginalized communities in the Ecuadorian Amazon.</p>  a1476-1645