01543nas a2200157   4500000000100000008004100001260003400042653001700076653002800093653002000121100001400141700001300155245009300168520109900261022002501360       2025                            d  bOxford University Press (OUP)10aPodoconiosis10anon-filarial lymphedema10aEarly diagnosis1 aEnbiale W1 aDeribe K00aPodoconiosis: A Comprehensive clinical review and Strategies for Control and Elimination3 a<p>Podoconiosis, a neglected tropical disease, manifests as non-filarial lymphedema, primarily affecting the lower limbs. It arises due to prolonged exposure of bare feet to irritant red clay soils in genetically susceptible individuals. The disease is preventable and manageable but remains a public health challenge in endemic areas, including several countries in Africa, Asia, and Latin America. This review explores the clinical spectrum, pathogenesis, diagnostic challenges, and strategies for prevention and management of podoconiosis. Early intervention, including consistent use of footwear and improved foot hygiene, can significantly reduce disease burden. Lymphoedema management packages, including compression therapy and nodulectomy, show promising outcomes in improving patients’ quality of life. However, structural barriers such as resource limitations, stigma, and limited awareness continue to hinder control efforts. Addressing these challenges through integrated care, advocacy, and investment in research offers a viable pathway to the elimination of podoconiosis.</p>
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