01833nas a2200229   4500000000100000008004100001260003000042653003900072653001800111653001800129653002500147653002900172653004100201100001500242700001100257700001200268700001100280245019700291300001200488520108500500020001801585       2025                            d  bSpringer Nature Singapore10aNeglected tropical diseases (NTDs)10aVulnerability10aHealth equity10aCommunity engagement10aResearch and development10aSustainable Development Goals (SDGs)1 aKurihara C1 aSaio T1 aGreco D1 aDhai A00aEthical Principles for the Sustainable Development of Drugs for Neglected Tropical Diseases in Neglected Populations: Facilitating Meaningful Participation of Vulnerable People and Communities  a245-2543 a<p>The changes in the 2024 Declaration of Helsinki (DoH) to promote the engagement of vulnerable people and communities will certainly contribute to innovative research and development (R&amp;D) of interventions for neglected tropical diseases (NTDs).</p>

<p>Firstly, this presupposes the establishment of robust community participation in all stages of the research to overcome structural inequalities in healthcare around the world. Secondly, counteracting previous cautionary measures that systematically excluded vulnerable populations from research will avoid perpetuating the vicious cycle of health disparities. Thirdly, with these changes in the 2024 DoH, research with vulnerable participants could be facilitated for their benefit. Above all, to protect against exploitation, post-trial benefit-sharing must be guaranteed.</p>

<p>This chapter reviews the improvement of the renewed DoH from the viewpoint of technological innovation from R&amp;D for NTDs in neglected populations (twice neglected) to achieve equitable and sustainable goals of global health.</p>
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