03470nas a2200361   4500000000100000008004100001260003700042653001800079653003900097653001400136653001500150653001200165653001100177653001500188100001500203700001300218700001300231700001200244700001000256700001300266700001300279700001900292700001300311700001300324700001100337700002300348245016500371856010300536300000900639490000600648520244000654022001403094       2025                            d  bPublic Library of Science (PLoS)10aMental Health10aNeglected tropical diseases (NTDs)10aSkin NTDs10aDepression10aAnxiety10aStigma10aDisability1 aSeekles ML1 aNganda M1 aKadima J1 aSempe L1 aKim J1 aOmumbu P1 aKukola J1 aNgenyibungi SM1 aNgondu F1 aSabuni L1 aDean L1 aMontague-Cardoso K00aPeace of mind: A quasi-experimental, mixed-method evaluation of a community-based mental health intervention for persons affected by Neglected Tropical Diseases  uhttps://journals.plos.org/mentalhealth/article/file?id=10.1371/journal.pmen.0000423&type=printable  a1-160 v23 a<p>Evidence consistently shows high levels of mental distress amongst populations affected by skin NTDs. Self-help groups are thought to be a key intervention strategy to support affected persons. However, to date, self-help interventions have largely been concerned with physical improvements as opposed to psychological outcomes. This paper provides an evaluation of the impact of the ‘Peace of Mind’ intervention in Kasai Province, DRC. Peace of Mind was a community-based, peer-led mental health intervention, combining lay counselling, mutual support, self-care, and income generation activities within a self-help group model to address health, psychosocial and economic impacts of skin-NTDs. This mixed-methods study used a quasi-experimental difference-in-difference approach. A survey measured levels of depression, anxiety, and stigma before and after intervention. To facilitate data matching, machine learning was used to predict (based on age, sex, health zone and disability status) which participants in the baseline would have attended the self-help groups. In addition, qualitative and participatory methods including photovoice, in-depth interviews and key informant interviews were completed to elicit the experiences of group members and health staff. Our findings show that after 6 months of intervention this holistic approach was effective at reducing levels of depression (PHQ-9 score reduction ranging on average from -3.5 to -6.7 points, p &lt; .05) and anxiety (GAD-7 score reduction from -2.0 to -3.3 points, p &lt; .05) in persons affected by skin NTDs. However, the prevalence of depression (64%) and anxiety (52%) remained high with suicidal thoughts reported by 35% of respondents at endline. Whilst we found no impact on stigma scores, qualitative data indicated improvements to self-esteem and ability to take part in community life. To our knowledge, this is the first study in the DRC to evaluate the impact of a community-based, peer-led intervention on mental health outcomes of persons affected by skin-NTDs. Holistic self-help groups have the potential to serve as a key component of integrated NTD/mental health service provision at community-level. However, this should be accompanied by the integration of stigma-reduction strategies, the strengthening of primary health care capacities, and the establishment of mental health services at secondary and tertiary care levels.</p>
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