02921nas a2200277 4500000000100000008004100001260003700042653001800079653001700097653001200114653001200126653002000138653002100158100001500179700001700194700002400211700001100235700001300246700001700259245009800276856009800374300000900472490000700481520214100488022001402629 2025 d bPublic Library of Science (PLoS)10aLeishmaniasis10aDrug Therapy10aFinance10aLesions10aQuality of Life10aHealth economics1 aGalvão EL1 aCarvalho JDP1 aMachado de Assis TS1 aCota G1 aSilva SN1 aSchriefer, A00aEffects of cutaneous leishmaniasis on health-related quality of life: A longitudinal approach uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0334215&type=printable a1-120 v203 a
Introduction
Cutaneous leishmaniasis (CL) is a neglected tropical disease that significantly affects patients’ physical, psychological, and social well-being. Although previous studies have documented health-related quality of life (HRQoL) impairments associated with CL, most have relied on cross-sectional data, providing only a snapshot of the disease burden. Few studies have examined HRQoL progression over time or explored treatment effects from the patient’s perspective.
Objectives
This study aimed to evaluate changes in HRQoL among CL patients at three time points: before treatment, during treatment, and after treatment, using the Cutaneous Leishmaniasis Impact Questionnaire (CLIQ).
Methods
A longitudinal observational study was conducted from October 2020 to April 2023 at a specialized center in Belo Horizonte, Brazil, involving 143 CL patients. The CLIQ was administered at diagnosis, during treatment (up to 30 days post-treatment), and at least 90 days after treatment initiation. Analyses included descriptive statistics, group comparisons using nonparametric methods, and correlation assessments based on rank-order relationships.
Findings
Of the 143 patients enrolled, 120 completed all assessments. Median CLIQ scores improved significantly from pre-treatment (24, IQR 16–36) to post-treatment (15, IQR 8.25–25; p < 0.001). Notable improvements were observed in physical symptoms, emotional distress, and daily functioning. However, financial burden and social isolation persisted after treatment. Patient dissatisfaction with health services peaked during treatment but decreased afterward.
Conclusion
Treatment significantly enhanced HRQoL in CL patients, particularly in the physical and functional domains. Nevertheless, persistent financial and emotional challenges underscore the need for comprehensive support interventions addressing economic and psychosocial dimensions, thereby promoting holistic care.
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