03454nas a2200613   4500000000100000008004100001260001200042653002800054653002500082653001100107653003900118653001700157653001000174653001600184653001600200100001300216700001300229700001200242700001200254700001700266700001500283700001200298700001600310700001300326700001400339700001400353700001400367700001300381700001500394700001500409700001700424700001400441700001500455700001400470700001200484700001300496700001600509700001500525700001300540700001600553700001400569700001700583700001400600700001900614700001400633700001600647700001300663700001600676245014800692856026000840300000901100520171701109022001402826       2025                            d  c10/202510aSchistosoma haematobium10aSchistosoma mattheei10ahybrid10aMale genital schistosomiasis (MGS)10aPraziquantel10aSemen10aLake Malawi10aShire River1 aMainga B1 aKayuni S1 aAhmed F1 aDeles G1 aCunningham L1 aKumwenda D1 aLally D1 aChammudzi P1 aKapira D1 aNamacha G1 aChisale A1 aNchembe T1 aKinley L1 aChibwana E1 aNkhalema B1 aChapweteka G1 aChibowa H1 aKumfunda V1 aJuhász A1 aJones S1 aArcher J1 aO'Ferrall A1 aRollason S1 aCawley A1 aCowlishaw R1 aNguluwe A1 aChiphwanya J1 aLuhanga M1 aKafaninkhale H1 aMakaula P1 aLaCourse JE1 aMusaya J1 aStothard RJ00aA longitudinal study of men with male genital schistosomiasis (MGS) in Southern Malawi associated with human, zoonotic and hybrid schistosomes.  uhttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/3F2FCE0D8D522D9BD9093247587F5027/S0031182025100942a.pdf/a-longitudinal-study-of-men-with-male-genital-schistosomiasis-mgs-in-southern-malawi-associated-with-human-zoonotic-and-hybrid-  a1-273 a<p>In sub-Saharan Africa’s endemic areas for urogenital schistosomiasis, Male Genital Schistosomiasis (MGS) can cause significant morbidity. As part of the Hybridization in UroGenital Schistosomiasis (HUGS) investigation, a MGS sub-study examined a cohort of adult men over a calendar year to better ascertain general infection dynamics and putative zoonotic schistosome transmission. During follow-up, demographic, health and socioeconomic data were collected through individual questionnaire interviews. Collected urine and semen were analysed using urine filtration, urine and semen microscopy and molecular DNA analyses of semen. Ten participants with reported MGS-associated symptoms had Schistosoma eggs in their urine and semen at 6 months’ follow up, with seven at 12 months. Ten out of eleven participants with S. haematobium eggs on semen microscopy at baseline had persistent infection at 6 months follow-up, together with 6 new participants, giving an MGS prevalence of 84.2% (n=19). Two also had S. mattheei eggs co-infection. Four of the 13 participants at 12 months follow-up had S. haematobium eggs in their semen which were persistent at all the time-points. Using semen PCR, 14 participants (73.7%) had Schistosoma infection at 6 months, with only 2 participants being infected for first time. Upon DNA analysis, three participants also had hybrid co-infection at this time-point. At 12 months, only six participants had Schistosoma infection with no hybrids detected. In summary, like S. haematobium and despite praziquantel treatment, both zoonotic and hybrid schistosomes can continue to cause MGS, which pose a further tangible challenge in future management and control measures.</p>
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