02092nas a2200241   4500000000100000008004100001653003900042653001500081653001800096653001300114653001700127100001800144700001100162700001400173700001400187700001800201700001800219700001100237245013900248856026000387300001400647520118900661       2025                            d10aNeglected tropical diseases (NTDs)10aMicrobiota10aImmune System10aPathogen10aInflammation1 aChuks Oranu E1 aOzoh M1 aMadueke E1 aEzeagha C1 aOnwuzuligbo C1 aChukwudulue U1 aMeko A00aThe role of gut microbiota in modulating immune responses to neglected tropical diseases: A new frontier in host-pathogen interactions  uhttps://www.researchgate.net/profile/Oranu_Emmanuel/publication/396855836_The_role_of_gut_microbiota_in_modulating_immune_responses_to_neglected_tropical_diseases_A_new_frontier_in_host-pathogen_interactions/links/68fb5320e7f5f867e6e20867/The-role-of-gut-  a1193-12023 a<p>Neglected tropical diseases (NTDs), such as Leishmaniasis, Chagas’ disease, and trypanosomiasis affect billions of people worldwide, particularly in low-income regions, and pose significant public health challenges. Emerging evidence suggests that gut microbiota play a crucial role in modulating immune responses to these infections, influencing disease progression and host defence mechanisms. This review examines the interplay between gut microbiota and the immune system in the context of NTDs, highlighting mechanisms such as microbial-mediated immune priming, modulation of inflammation, and interactions with pathogenic organisms. Dysbiosis—an imbalance in gut microbiota—has been implicated in exacerbating NTDs pathogenesis, while microbiome-targeted interventions offer potential therapeutic strategies. A deeper understanding of host-microbiota interactions may facilitate the development of novel approaches to NTDs management, integrating microbiome modulation into existing treatment and preventive frameworks. Further research is necessary to elucidate specific microbial signatures associated with NTDs and their potential for therapeutic exploitation.</p>