03369nas a2200445   4500000000100000008004100001260003700042653002100079653001200100653003100112653001100143653002400154653001300178100001300191700001300204700001300217700001300230700001400243700001200257700001300269700001200282700001200294700001600306700001300322700001300335700001600348700001200364700001100376700001400387700001500401700001400416700001300430700001900443245015200462856009900614300000900713490000700722520218000729022001402909       2025                            d  bPublic Library of Science (PLoS)10aSchistosomiasis 10aSchools10aSoil-transmitted helminths10aGuinea10aSchistosoma mansoni10aChildren1 aKeita BM1 aDiallo M1 aDiarra M1 aTraore S1 aKamano AT1 aKeita D1 aAmento A1 aSylla M1 aKante N1 aDopavogui A1 aSylla CM1 aBerete S1 aVounatsou P1 aKepha S1 aGass K1 aPullan RL1 aFleming FM1 aDiallo NK1 aKonde MK1 aTaylan Ozkan A00aPiloting the Schistosomiasis Practical and Precision Assessment approach in five health districts of the N’zérékoré region, Republic of Guinea  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0013413&type=printable  a1-130 v193 a<p><strong>Background</strong></p>

<p>In Guinea, N’Zérékoré region has historically been endemic for both Schistosoma mansoni and S. haematobium. Following eight years of mass treatment with praziquantel to treat schistosomiasis, as part of a multi-country project, the country was selected to pilot the Schistosomiasis Practical and Precision Assessment (SPPA) approach. The SPPA pilot was conducted in five health districts in the forest region. The main objectives were to determine the current infection status and treatment strategy for each health sub-district and to evaluate the feasibility of the SPPA approach.</p>

<p><strong>Methodology/Principal findings</strong></p>

<p>A cross-sectional study among children aged 10–14 years of age was conducted. In each health district, a systematic sample of 15 schools were selected with 32 school children selected randomly from each. Stool and urine samples were collected from each child. Two Kato-Katz slides were examined for S. mansoni and soil transmitted helminthiasis (STH) and one urine filtration slide and one hemastix for S. haematobium infections and microhaematuria, respectively. Of the 2400 children targeted for inclusion, 2325 provided samples (96.9%). The combined prevalence of Schistosoma species across the five health districts was 66.4%. S. mansoni had a high prevalence of 66.1% with four health districts above 50%. S. haematobium had a low prevalence of 4.3%. The overall prevalence of any combined STH (Ascaris lumbricoides, Trichuris trichiura or hookworm) was 11.7%. Sex, age and contact with a freshwater body during the last week before the survey, were not statistically significant in their association with schistosomiasis.</p>

<p><strong>Conclusion</strong></p>

<p>The results of the SPPA indicate that schistosomiasis remains homogeneously high across all five health districts. Consequently, it is recommended to maintain annual treatment in each sub-health district, and to extend treatment to whole communities aged two years of age and over, while strengthening critical cross-sectoral interventions such as behaviour change and environmental management.</p>
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