01623nas a2200193   4500000000100000008004100001260001200042653002300054653002700077653002000104653001700124653002100141653003000162100001100192700001100203245015000214520105100364022001401415       2026                            d  c03/202610aEthical principles10aCommunity perspectives10adata protection10aData sharing10aInformed Consent10ascreening of participants1 aAyuk A1 aVubo E00aCommunity Perspectives on Ethical Considerations in Clinical Research: Lessons from the ESRIFAL Clinical Trial in the Meme River Basin, Cameroon.3 a<p>The study explored community perspectives on ethical considerations in clinical research, focusing on the ESRIFAL trial conducted in Cameroon. The hermeneutic phenomenological approach was used to analyze and interpret the data. Participants were selected by systematic sampling. In-depth interviews were used to gather data from the participants. Some findings revealed that while ethical principles such as informed consent are highly recommended in clinical trials, participants did not understand and interpret these documents with as much importance as expected. Participants had other priorities and objectives for engaging in the trial; getting rid of the disease onchocerciasis was one of them. Signing the forms was nothing more than a formality for them. In conclusion, the study emphasizes the importance of strengthening ethical oversight mechanisms, but more importantly, the fact that ethical principles need to be contextualized to fit into the social and cultural realities of the societies in which trials are implemented.</p>  a1556-2654