01605nas a2200253   4500000000100000008004100001260001200042653001600054653002000070653002000090653003500110653001100145653001300156100001500169700001300184700001200197700001600209245006700225856007000292300001200362490000700374520095600381022001401337       2026                            d  c05/202610aSchistosoma10abiopsychosocial10aeconomic burden10aHealth-related quality of life10aImpact10aphysical1 aOsakunor D1 aAlonso S1 aJumbe S1 aLamberton P00aUnravelling the true biopsychosocial impact of schistosomiasis  uhttps://www.cell.com/action/showPdf?pii=S1471-4922%2826%2900075-9  a408-4250 v423 a<p>Schistosomiasis remains a debilitating parasitic disease, with over 200 million people infected globally. Heavy, chronic infections cause severe morbidity and over 12 000 deaths a year. As diagnostics improve, we have a greater understanding of more accurate prevalences. However, how infections, including light-intensity infections, affect individuals' health and quality of life remains to be fully understood, particularly as specific markers of morbidity, disease progression, and resolution are lacking. We explore evidence about the true broader physical, psychological, economic, social, and environmental impacts of schistosomiasis, identifying critical gaps in understanding the interplay between infection, morbidity, and wellbeing, and propose innovative approaches to better capture true long-term disease impacts. We argue for more holistic frameworks to inform disease monitoring, intervention evaluation, and policy development.</p>  a1471-5007