02472nas a2200169   4500000000100000008004100001260001200042653002200054653002400076653002900100653001700129100001700146245013900163856008100302300001100383520190800394       2026                            d  c08/202610aZoonotic diseases10aOne Health approach10aAntimicrobial resistance10asurveillance1 aSara Basiri 00aIntegrated One Health Approaches to Zoonotic Disease Control and Antimicrobial Resistance: From Policy Barriers to Practical Solutions  uhttps://jzd.tabrizu.ac.ir/article_22031_d1db3ec6f4aee5cff57e207da825db13.pdf  a1 - 183 a<p>Zoonotic diseases continue to pose significant threats to global health, food systems, and socioeconomic stability, driven by the intricate interdependence of humans, animals, and the environment. This review synthesizes current knowledge within a One Health framework to examine how ecological processes, environmental reservoirs, and human activities shape the emergence and transmission of zoonotic pathogens and antimicrobial resistance. Environmental compartments such as soil, water, and polluted ecosystems act as reservoirs for pathogens and resistance genes. At the same time, climate change, habitat disruption, and pollution alter disease dynamics and increase the potential for spillover. Human-driven factors—including urban expansion, deforestation, wildlife exploitation, and globalized food production—further intensify transmission pathways. The review evaluates surveillance systems, biosecurity practices, and stewardship policies across diverse settings, highlighting persistent gaps in diagnostic capacity, infrastructure, and cross-sectoral coordination, particularly in resource-limited regions. Emerging alternatives to conventional antibiotics, including bacteriophage therapy, anti-virulence strategies, and microbiome based interventions, are discussed as complementary tools to mitigate antimicrobial resistance. The analysis also integrates animal welfare and food security considerations, emphasizing that sustainable agriculture, healthy livestock systems, and environmental integrity are essential for resilient food supplies and effective zoonotic disease prevention. By unifying these domains, the review proposes a coordinated roadmap that strengthens surveillance, enhances stewardship, and promotes collaborative action across human, animal, and environmental sectors to improve preparedness and resilience against current and future infectious threats.</p>