02441nas a2200385   4500000000100000008004100001260001200042653001800054653003200072653001800104653002300122653003900145653002400184100001300208700001100221700001200232700001300244700001400257700001500271700001400286700001400300700001900314700001400333700002800347700001300375700001300388700001300401700001300414245011800427856007700545300001100622490000700633520140100640022001402041       2026                            d  c08/202610abenzimidazole10abioorganometallic chemistry10aLeishmaniasis10ametals in medicine10aNeglected tropical diseases (NTDs)10aparasitic helminths1 aLudwig C1 aTaki A1 aByrne J1 aMesdom P1 aBlacque O1 aHäberli C1 aZumkehr T1 aScalese G1 aPérez-Díaz L1 aGambino D1 aLundström-Stadelmann B1 aKeiser J1 aGasser R1 aCariou K1 aGasser G00aSynthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs.  uhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13453072/pdf/CBIC-27-e70490.pdf  a1 - 160 v273 a<p>About 50 years after their development, the benzimidazole anthelmintic drugs still occupy a key role in the treatment of parasitic diseases. Like other anti-infective drugs, their extensive use has led to resistance development and now requires new solutions to treat these diseases. Organometallic derivatization of existing drugs has become a common strategy to design new drug candidates, which could benefit from enhanced activity against resistant or sensitive strains through the incorporation of an organometallic fragment. In this study, we describe the development of a new series of organometallic derivatives of benzimidazole anthelmintics. Ten derivatives, six of which were organometallic, were synthesized and characterized. In silico and in vitro studies were performed to determine their biological activity. Therefore, they were screened against a range of nematodes and other parasites. Biological activities were found for some of the derivatives against Strongyloides ratti, Ancylostoma ceylanicum, Trichuris muris, Schistosoma mansoni, Echinococcus multilocularis, or Leishmania infantum in similar ranges as the parent anthelmintics. Even if the activity of the benzimidazole scaffold was not systematically enhanced, this strategy is a good starting point for the development of new antiparasitic compounds and for further study of the mode of action of these drugs.</p>  a1439-7633