03976nas a2200541   4500000000100000008004100001260004600042653000900088653001300097653001300110653003600123653003200159653002300191653001400214653001000228100001700238700001200255700001300267700001200280700001500292700001400307700001800321700001700339700002400356700001200380700001300392700001400405700001100419700001000430700001600440700001400456700001300470700001800483700001400501700001600515700001800531700001400549700001300563700001400576700001200590700001300602245015300615856009900768300001100867490000700878520253500885022001403420       2026                            d  c07/2026bPublic Library of Science (PLoS)10aLaos10aZoonoses10aCambodia10ainfectious disease surveillance10aZoonotic neglected diseases10azoonotic pathogens10aLivestock10aSwine1 aBlacksell SD1 aWard MP1 aYoung JR1 aBush RD1 aWindsor PA1 aKhounsy S1 aPhommachanh P1 aTheppangna W1 aSiengsanan-Lamont J1 aBurns R1 aTurner P1 aGilbert J1 aKong L1 aTum S1 aKarlsson EA1 aConlan JV1 aHughes T1 aKolenchery JB1 aRoberts T1 aRobinson MT1 aVongsouvath M1 aNewton PN1 aMayxay M1 aAshley EA1 aDay NPJ1 aPappas G00aZoonotic neglected tropical diseases at the animal-human interface in the Greater Mekong Subregion: Two decades of surveillance in Laos and Cambodia  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0014584&type=printable  a1 - 310 v203 a<jats:p>
                    Zoonotic neglected tropical diseases (NTDs) remain a substantial but under-recognised source of human morbidity and economic concern in the Greater Mekong Subregion, particularly in settings characterised by close human–animal interaction. This article represents a narrative synthesis of zoonotic disease research conducted in Laos and Cambodia between 2000 and 2025. The review integrates published literature with findings from long-term surveillance programmes conducted by the authors and collaborating institutions in Laos, with comparative insights from Cambodia, to examine the presence, distribution, diversity, and drivers of zoonotic pathogens at the human–animal interface. Evidence demonstrates the endemic presence of a wide range of parasitic, bacterial, and viral zoonoses, including
                    <jats:italic>Taenia solium</jats:italic>
                    ,
                    <jats:italic>Trichinella</jats:italic>
                    spp.,
                    <jats:italic>Streptococcus suis</jats:italic>
                    , rickettsial infections, melioidosis, hepatitis E virus, and Japanese encephalitis virus. Some of these pathogens are sustained within smallholder livestock systems, informal slaughter, farming practises, food networks, and wet market environments, where limited diagnostic capacity and fragmented surveillance obscure true disease presence. Surveillance innovations, including abattoir-based sampling, cross-sectoral serological studies, environmental surveillance approaches, and molecular diagnostic tools, have improved pathogen detection but have also highlighted persistent structural and behavioural barriers to control. Socio-cultural practices, occupational exposure, wildlife trade, and economic dependencies reinforce transmission dynamics, indicating that biomedical interventions alone are insufficient. Instead, zoonotic disease persistence reflects the interaction of livestock production systems, environmental conditions, diagnostic limitations, and entrenched human behaviours. This review emphasises the need for integrated One Health approaches that combine strengthened surveillance, improved diagnostics, behavioural interventions, and regional collaboration. Addressing zoonotic NTDs in Laos and Cambodia requires coordinated strategies that account for both biological complexity and socio-economic context to achieve sustainable disease control and improved public health outcomes.
                  </jats:p>  a1935-2735