01709nas a2200289   4500000000100000008004100001260002500042653002300067653000900090653001100099653001400110653002100124653001700145100001300162700001500175700001500190700001100205700001400216700001600230700001300246700001500259245006900274856015100343300001100494520090000505022001401405       2026                            d  c09/2026bElsevier BV10aTrypanosoma Brucei10aSkin10aDermis10areservoir10adifferentiation 10aTransmission1 aSharma P1 aEl Kadri M1 aBucheton B1 aBart J1 aMacLeod A1 aJamonneau V1 aCamara M1 aRotureau B00aSkin is a critical interface for Trypanosoma brucei transmission  uhttps://www.sciencedirect.com/science/article/pii/S1471492226002837/pdf?md5=027936d84b2f916838a584cbeca5cd09&pid=1-s2.0-S1471492226002837-main.pdf  a1 - 253 a<p>Trypanosoma brucei is transmitted by the tsetse fly bite and causes animal and human African trypanosomias e s. Sleeping sickness due to Trypanosoma brucei gambiense is targeted for elimination by the WHO. Traditionally viewed as bloodstream parasite s, th e trypanosome ’ s distribution has been reconsidered since T. brucei is in fact primarily present in extravascular spaces, particularly in the skin. These skin -dwelling forms remain poorly characterized but have profound implications in transmission and could impact diagnosis, treatment, and elimination efforts. We propose the dermis as a critical compartment, serving as both an anatomical reservoir sustaining parasite persistence and a direct interface between hosts. This article will focus on skin - resident parasites to review current knowledge and formulate key research questions that warrant further investigation.</p>
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