02213nas a2200277   4500000000100000008004100001260000900042653001200051653002300063653000900086653001200095100002100107700002100128700002000149700002300169700001200192700002500204700002000229700002500249245008500274856008000359300001100439050002400450520144700474022001401921       2013                            d  c201310aleprosy10aGene polymorphisms10aTLRs10aMexico.1 aMontoya-Buelna M1 aFafutis-Morris M1 aTovar-Cuevas AJ1 aAlvarado-Navarro A1 aValle Y1 aPadilla-Gutierrez JR1 aMuñoz-Valle JF1 aFiguera-Villanueva L00aRole of toll-interacting protein gene polymorphisms in leprosy mexican patients.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835875/pdf/BMRI2013-459169.pdf  a459169  aMONTOYA-BUELNA 20133 aBackground. Leprosy is a debilitating infectious disease of human skin and nerves. Genetics factors of the host play an important role in the disease susceptibility. Toll-interacting protein (TOLLIP) is an inhibitory adaptor protein within the toll-like receptor (TLR) pathway, which recognizes structurally conserved molecular patterns of microbial pathogens, initiating immune responses. The objective of this study was to investigate the association of variants in the TOLLIP gene with susceptibility to leprosy in Mexican patients. Methods. TOLLIP polymorphisms were studied using a case-control design of Mexican patients with lepromatous leprosy (LL). The polymorphisms of TOLLIP at loci -526 C>G (rs5743854), 1309956C>T (rs3750920), 1298430C>A (rs5744015), and 1292831 G>A (rs3750919) were analyzed by PCR, with sequence-specific primers in LL patients and healthy subjects (HS) as controls. Results. Genotype distributions were in Hardy Weinberg equilibrium for all sites except for rs3750920. Neither genotype nor allele frequencies were statistically different between LL patients and controls (P > 0.05). The maximum pairwise D' coefficient reached was 0.44 of linkage (P = 0.01) for all the polymorphisms except for rs5743854. The three loci haplotype comparison yielded no significant differences between groups. Conclusions. Just the individuals with genotype C/C of rs3750920 have a trend of protective effect to developing LL.  a2314-6141