02298nas a2200565   4500000000100000008004100001653003900042653001500081653000900096100001200105700001500117700001300132700001500145700001300160700001700173700001400190700001300204700001300217700001200230700001400242700001400256700001300270700001200283700001400295700001700309700001200326700001300338700001100351700001300362700001400375700001500389700001100404700001300415700001400428700001400442700001500456700001300471700001200484700001600496700001500512700001100527700001300538700001400551700001300565245011400578856007700692300001000769490000600779520094700785       2014                            d10aNeglected tropical diseases (NTDs)10aDisability10aDALY1 aHotez P1 aAlvarado M1 aáñez G1 aBolliger I1 aBourne R1 aBoussinesq M1 aBrooker S1 aBrown AS1 aBuckle G1 aBudke C1 aCarabin H1 aCoffeng L1 aèvre EM1 aürst T1 aHalasa YA1 aJasrasaria R1 aJohns N1 aKeiser J1 aKing C1 aLozano R1 aMurdoch M1 aO'Hanlon S1 aPion S1 aPullan R1 aRamaiah K1 aRoberts T1 aShepard DS1 aSmith JL1 aStolk W1 aUndurraga E1 aUtzinger J1 aWang M1 aMurray C1 aNaghavi M1 aSilva NR00aThe global burden of disease study 2010: Interpretation and implications for the neglected tropical diseases.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109880/pdf/pntd.0002865.pdf  ae28650 v83 a<p>The publication of the Global Burden of Disease Study 2010 (GBD 2010) and the accompanying collection of Lancet articles in December 2012 provided the most comprehensive attempt to quantify the burden of almost 300 diseases, injuries, and risk factors, including neglected tropical diseases (NTDs) [1]–[3]. The disability-adjusted life year (DALY), the metric used in the GBD 2010, is a tool which may be used to assess and compare the relative impact of a number of diseases locally and globally [4]–[6]. Table 1 lists the major NTDs as defined by the World Health Organization (WHO) [7] and their estimated DALYs [1]. With a few exceptions, most of the NTDs currently listed by the WHO [7] or those on the expanded list from PLOS Neglected Tropical Diseases [8] are disablers rather than killers, so the DALY estimates represent one of the few metrics available that could fully embrace the chronic effects of these infections.</p>