01447nas a2200145   4500000000100000008004100001653008500042100002100127245005500148856007700203300001000280490000800290520098900298022001401287       2015                            d10aChromoblastomycosis; Dematiaceous fungi; Fungal infections; Antifungal treatment1 aQueiroz-Telles F00aChromoblastomycosis: a neglected tropical disease.  uhttp://www.scielo.br/pdf/rimtsp/v57s19/0036-4665-rimtsp-57-s19-00046.pdf  a46-500 v57 3 a<p>Chromoblastomycosis (CMB) is a chronic fungal infection of the skin and the subcutaneous tissue caused by a transcutaneous traumatic inoculation of a specific group of dematiaceous fungi occurring mainly in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long term therapy with systemic antifungals, sometimes associated with physical methods. Unlike other neglected endemic mycoses, comparative clinical trials have not been performed for this disease. Nowadays, therapy is based on a few open trials and on expert opinion. Itraconazole either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been successfully employed in combination with antifungals in patients presenting with CBM. In the present revision the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.</p>
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