02412nas a2200325   4500000000100000008004100001100001400042700001300056700001700069700001700086700001300103700001600116700001400132700001300146700001400159700001900173700001500192700001700207700001300224700001500237700001300252700001400265700001300279245005100292856008700343300000700430490000600437520162900443022001402072       2016                            d1 aCuevas RA1 aLawson L1 aAl-Sonboli N1 aAl-Aghbari N1 aArbide I1 aSherchand J1 aNnamdi EE1 aAseffa A1 aYassin MA1 aAbdurrahman ST1 aObasanya J1 aOlanrewaju O1 aDatiko D1 aTheobald S1 aRamsay A1 aSquire BS1 aCuevas L00aPatients direct costs to undergo TB diagnosis.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806474/pdf/40249_2016_Article_117.pdf  a240 v53 a<p><strong>BACKGROUND: </strong>A major impediment to the treatment of TB is a diagnostic process that requires multiple visits. Descriptions of patient costs associated with diagnosis use different protocols and are not comparable.</p>

<p><strong>METHODS: </strong>We aimed to describe the direct costs incurred by adults attending TB diagnostic centres in four countries and factors associated with expenditure for diagnosis. Surveys of 2225 adults attending smear-microscopy centres in Nigeria, Nepal, Ethiopia and Yemen. Adults &gt;18&nbsp;years with cough &gt;2&nbsp;weeks were enrolled prospectively. Direct costs were quantified using structured questionnaires. Patients with costs &gt;75(th) quartile were considered to have high expenditure (cases) and compared with patients with costs &lt;75(th) quartile to identify factors associated with high expenditure.</p>

<p><strong>RESULTS: </strong>The most significant expenses were due to clinic fees and transport. Most participants attended the centres with companions. High expenditure was associated with attending with company, residing in rural areas/other towns and illiteracy.</p>

<p><strong>CONCLUSIONS: </strong>The costs incurred by patients are substantial and share common patterns across countries. Removing user fees, transparent charging policies and reimbursing clinic expenses would reduce the poverty-inducing effects of direct diagnostic costs. In locations with limited resources, support could be prioritised for those most at risk of high expenditure; those who are illiterate, attend the service with company and rural residents.</p>
  a2049-9957