01998nas a2200241   4500000000100000008004100001653002400042653002100066653003300087653001400120653001700134653001100151100002000162700001900182700001400201700001700215245009500232856020500327300001000532490000600542520119500548022001301743       2016                            d10aTime trend analysis10aSpatial analysis10aNegelected Tropical Diseases10aMortality10aEpidemiology10aBrazil1 aMartins-Melo FR1 aNovaes Ramos A1 aAlencar C1 aHeukelbach J00aTrends and spatial patterns of mortality related to neglected tropical diseases in Brazil.  uhttps://www.researchgate.net/profile/Alberto_Ramos_Jr/publication/299845110_Trends_and_spatial_patterns_of_mortality_related_to_neglected_tropical_diseases_in_Brazil/links/570629b508ae44d70ee352a2.pdf  a56-650 v13 a<p>We analysed nationwide trends and spatial distribution of NTD-related mortality in Brazil. We included all death certificates in Brazil from 2000 to 2011, in which NTDs were recorded as any causes of death. A total of 100,814/12,491,280 (0.81%) death certificates were identified, which mentioned at least one NTD. Age-adjusted NTD-related mortality rates showed a significant decrease over time (annual percent change [APC]: −2.1%; 95% CI: −2.8 to −1.3), with decreasing mortality rates in the Southeast, South, and Central-West regions, stability in the Northeast region, and increase in the North region. We identified spatial and spatiotemporal high-risk clusters for NTD-related mortality in all regions, with a major cluster covering a wide geographic range in central Brazil. Despite nationwide decrease of NTD-related mortality in the observation period, regional differences remain, with increasing mortality trends especially in the socioeconomically disadvantaged regions of the country. The existence of clearly defined high-risk areas for NTD-related deaths reinforces the need for integrated prevention and control measures in areas with highest disease burden.</p>
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