01467nas a2200229   4500000000100000008004100001653000900042653001400051653001400065653001500079100001500094700001800109700001400127700001800141700001500159245010000174856007900274300001000353490000700363520085300370022001401223       2016                            d10aZika10aPregnancy10aMigration10aDiagnsosis1 aNicastri E1 aCastilletti C1 aDi Caro A1 aCapobianchi M1 aIppolito G00aDiagnosis of Zika virus infection in pregnant women travelling to or residing in endemic areas.  uhttp://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(16)30074-3.pdf  a771-20 v163 a<p>Guilherme Calvet and colleagues reported the detection and sequencing of Zika virus from amniotic fluid. The two pregnant women from the state of Paraiba in Brazil experienced a Zika-like febrile illness at weeks 18 and 10 of gestation. IgM serology and qRT-PCR for Zika virus were done in both patients in serum, urine, and amniotic fl uid samples, and reported positive for Zika virus only in amniotic fluids. Absence of a positive Zika virus serology in serum and urine is noteworthy and raises concerns in terms of proper diagnosis and clinical management of febrile syndromes in pregnant women resident in or travelling to Zika-endemic countries. No standardised diagnostic tests are commercially available for Zika virus infection and all diagnosis is based on homemade methods restricted to highly specialised virology laboratories.</p>
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