02135nas a2200229   4500000000100000008004100001653002900042653001900071653001100090653001800101653002800119100001400147700001600161700001400177700001300191245015200204856009000356300001000446490000600456520142900462022001401891       2013                            d10aTrypanosomiasis, African10aonchocerciasis10aHumans10aGlobal health10aElephantiasis, Filarial1 aTediosi F1 aSteinmann P1 aSavigny D1 aTanner M00aDeveloping eradication investment cases for onchocerciasis, lymphatic filariasis, and human African trypanosomiasis: rationale and main challenges.  uhttp://journals.plos.org/plosntds/article/asset?id=10.1371%2Fjournal.pntd.0002446.PDF  ae24460 v73 a<p>The global health community pays renewed attention to evaluating the feasibility of elimination and eradication of certain communicable diseases <a class="ref-tip" href="http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0002446#pntd.0002446-Cochi1">[1]</a>, <a class="ref-tip" href="http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0002446#pntd.0002446-Cochi2">[2]</a> besides continuing to reduce the burden of ill-health. Eradication depends on both the availability of tools to interrupt transmission, the capacity of health systems to implement these solutions effectively across all populations concerned, the required resources, and sustained political will. While the health and economic benefits of disease elimination and subsequent eradication may be substantial, elimination initiatives represent resource-intensive efforts with associated opportunity costs <a class="ref-tip" href="http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0002446#pntd.0002446-Miller1">[3]</a>, <a class="ref-tip" href="http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0002446#pntd.0002446-Eradication1">[4]</a>. Given the increasingly intense competition for global health resources, the decision to commit to national/regional elimination or eventual global eradication initiatives needs to be based upon robust analysis of benefits, risks, and costs.</p>
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