01886nas a2200349   4500000000100000008004100001653001300042653001300055653001700068653000900085653001100094653001400105653001100119653001100130653002400141653001600165653001900181653001300200653002600213653002100239653001000260100001300270700001300283700001300296700001400309700001400323245008200337300001100419490000600430520108600436022001401522       2001                            d10aTrachoma10aTanzania10aRisk Factors10aMale10aInfant10aIncidence10aHumans10aFemale10aDisease Progression10aConjunctiva10aCohort Studies10aCicatrix10aChlamydia trachomatis10aChild, Preschool10aChild1 aWest S K1 aMuñoz B1 aMkocha H1 aHsieh Y H1 aLynch M C00aProgression of active trachoma to scarring in a cohort of Tanzanian children.  a137-440 v83 a<p>Risk factors for the incidence of scarring are needed to inform trachoma control programs in countries hyperendemic for this blinding disease. A cohort of pre-school children with constant, severe trachoma, and an age, sex, and neighborhood matched cohort of children without constant severe trachoma were followed for seven years to determine the incidence of scarring. The incidence of scarring in the children with constant severe trachoma was 29.2% versus 9.6% in the comparison group. In a model adjusting for multiple factors, significant predictors of scarring were increasing age, female, and constant severe trachoma (OR = 4.85, 95% CL = 2.05, 11.40). Infection with C. trachomatis at follow up was also associated with scarring in both groups of children. It is likely that these children have a different host response to infection, and represent a subgroup at high risk for the blinding complications of trachoma. Reducing exposure to infection in the community through antibiotics and changes in hygiene practices is still the most promising control strategy.</p>
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