01221nas a2200181   4500000000100000008004100001260001300042653001500055653003900070653002800109100001400137700001200151700001600163245006700179300001200246490000700258520077400265       2017                            d  bElsevier10aWound care10arandomized controlled trials (RCT)10aEvidence-Based Medicine1 aCutting K1 aWhite R1 aLegerstee R00aEvidence and practical wound care–An all-inclusive approach.  a40–450 v163 a<p>The quest for evidence-based medicine leads one in search of best available evidence but what exactly is this? Convention guides us towards the putative gold standard of the randomised controlled trial (RCT) but this approach provides limited access to the gathering of evidence that is relevant to a ‘real world’ environment. Taking several examples from wound care including moist wound healing, negative pressure wound therapy and dressing wounds with gauze we show that if one takes biology into consideration, the “truth” becomes more relevant to everyday life. We suggest that solely relying on the RCT in the quest for truth is misguided and that the research community should embrace a circular model of evidence rather than a hierarchical one.</p>