01897nas a2200289   4500000000100000008004100001653003100042653003900073653000800112653001400120653001400134653001600148100001200164700001500176700001400191700001200205700002100217700001300238700001300251700001300264245006500277250000800342856003300350300001400383490000600397520120400403       2017                            d10aSoil-transmitted helminths10aNeglected tropical diseases (NTDs)10aMDA10aDeworming10aChildhood10aadolescence1 aBundy D1 aAppleby LJ1 aBradley M1 aCroke K1 aHollingsworth DT1 aPullan R1 aTurner H1 aSilva NR00aMass deworming programs in middle childhood and adolescence.  a3rd  uhttps://tinyurl.com/y83428c2  a165 - 1820 v83 a<p>Reports that soil-transmitted helminthes (STH) deworming programs remain among the largest public health programs in low- and lower-middle-income countries as measured by coverage. The actual scale of these programs remains unknown but substantial, with more than 1 billion donated doses of medicines effective against STHs delivered by formal programs and supplemented by widespread self-treatment and unprogrammed activities. STH infection declines worldwide likely reflect the influence of improved hygiene and sanitation associated with global declines in poverty, but it also reflects control efforts during the twentieth century that have largely eliminated STHs as a public health problem in previously endemic areas of North America (Mexico and the United States), Japan, Korea, and upper- middle-income countries throughout southern and eastern Asia. Much of the treatment targets delivery through schools and targets school-age children. STH infection associates with clinical and developmental outcomes that prove largely reversible by treatment. Both historical and contemporary trials of targeted treatment of infected individuals have also demonstrated benefit from treatment.</p>