02021nas a2200217   4500000000100000008004100001653003500042653002400077653001200101653002700113653002800140100001500168700002100183700001500204700001400219245010200233856003300335300000600368520141500374022001401789       2018                            d10amass drug administration (MDA)10aInfectious Diseases10aMalaria10aMathematical modelling10aSeasonal human movement1 aGerardin J1 aBertozzi-Villa A1 aEckhoff PA1 aWenger EA00aImpact of mass drug administration campaigns depends on interaction with seasonal human movement.  uhttps://tinyurl.com/ybd6qhdd  a63 a<p><strong>Background: </strong>Mass drug administration (MDA) is a control and elimination tool for treating infectious diseases. For malaria, it is widely accepted that conducting MDA during the dry season results in the best outcomes. However, seasonal movement of populations into and out of MDA target areas is common in many places and could potentially fundamentally limit the ability of MDA campaigns to achieve elimination.</p>

<p><strong>Methods: </strong>A mathematical model was used to simulate malaria transmission in two villages connected to a high-risk area into and out of which 10% of villagers traveled seasonally. MDA was given only in the villages. Prevalence reduction under various possible timings of MDA and seasonal travel was predicted.</p>

<p><strong>Results: </strong>MDA is most successful when distributed outside the traveling season and during the village low-transmission season. MDA is least successful when distributed during the traveling season and when traveling overlaps with the peak transmission season in the high-risk area. Mistiming MDA relative to seasonal travel resulted in much poorer outcomes than mistiming MDA relative to the peak transmission season within the villages.</p>

<p><strong>Conclusions: </strong>Seasonal movement patterns of high-risk groups should be taken into consideration when selecting the optimum timing of MDA campaigns.</p>
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