01651nas a2200181   4500000000100000008004100001653003900042653001400081653001600095653002200111653003000133100001200163700001200175245005600187856005700243300001200300520115700312       2018                            d10aNeglected tropical diseases (NTDs)10asnakebite10aDendrotoxin10aMamba snake venom10aNeurological implications1 aKumar A1 aGupta V00aNeurological implications of dendrotoxin: A review.  uhttps://www.ecronicon.com/ecpt/pdf/ECPT-06-00187.pdf  a469-4763 a<p>Dendrotoxin, the most potent component of Mamba snake venom is considered to be majorly responsible for the exceedingly high rate of morbidity and mortality observed in Mamba snake victims. Studies suggest that in addition to inducing toxicity in the brain and other organs, the footprints of dendrotoxin can also be seen in various other neurological and physiological conditions. The understanding of dendrotoxin has been further deepened by its applications in neurophysiology. Studies have been done on the binding of dendrotoxin at various sites in the brain, therefore suggesting a pathological connection. In this review, authors highlight the involvement of dendrotoxin in diverse neurological conditions either in the induction of direct neurotoxicity or having the potential to be involved in the pathology of various neurological disorders. The authors also explain here the molecular mechanisms associated with dendrotoxin along with other components of mamba venom. Need for the search of a potent, yet safer drug candidate, which can be effective in cases of delayed medical assistance in mamba snake victims, is also urged upon.</p>