01523nas a2200217   4500000000100000008004100001653001300042653001400055653002700069653002300096100002500119700002200144700002300166700001900189245007500208856009900283300001300382490000700395520088900402022001401291       2019                            d10aAmericas10aAntivenom10aAntivenom availability10aSnake envenomation1 aCastillo-Beltrán MC1 aHurtado-Gómez JP1 aCorredor-Espinel V1 aRuiz-Gómez FJ00aA polyvalent coral snake antivenom with broad neutralization capacity.  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007250&type=printable  ae00072500 v133 a<p>Coral snakes of the genus Micrurus have a high diversity and a wide distribution in the Americas. Despite envenomings by these animals are uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom.</p>
  a1935-2735