02641nas a2200529   4500000000100000008004100001260002300042653001400065653003700079100001200116700001400128700001400142700001300156700001400169700001300183700001200196700001200208700001200220700001600232700001100248700001400259700001400273700001200287700001500299700001300314700001100327700001300338700001000351700001300361700001400374700001200388700001400400700001600414700001300430700001400443700001100457700001500468700001900483700001900502700001400521700001200535245016200547300001200709490000700721520135800728022002502086       2019                            d  bInforma UK Limited10aDeworming10aSoil-transmitted helminths (STH)1 aWelch V1 aHossain A1 aGhogomu E1 aRiddle A1 aCousens S1 aGaffey M1 aArora P1 aBlack R1 aBundy D1 aChristine M1 aChen L1 aDewidar O1 aElliott A1 aFriis H1 aDéirdre T1 aHorton S1 aKing C1 aLe Thi H1 aLiu C1 aRohner F1 aRousham E1 aSalam R1 aSartono E1 aSteinmann P1 aSupali T1 aTugwell P1 aWebb E1 aWieringa F1 aWinnichagoon P1 aYazdanbakhsh M1 aBhutta ZA1 aWells G00aDeworming children for soil-transmitted helminths in low and middle-income countries: systematic review and individual participant data network meta-analysis  a288-3060 v113 aIntestinal parasites affect millions of children globally. We aimed to assess effects of deworming children on nutritional and cognitive outcomes across potential effect modifiers using individual participant data (IPD). We searched multiple databases to 27 March 2018, grey literature, and other sources. We included randomised and quasi randomised trials of deworming compared to placebo or other nutritional interventions with data on baseline infection. We used a random-effects network meta-analysis with IPD and assessed overall quality, following a pre-specified protocol. We received IPD from 19 trials of STH deworming. Overall risk of bias was low. There were no statistically significant subgroup effects across age, sex, nutritional status or infection intensity for each type of STH. These analyses showed that children with moderate or heavy intensity infections, deworming for STH may increase weight gain (very low certainty). The added value of this review is an exploration of effects on growth and cognition in children with moderate to heavy infections as well as replicating prior systematic review results of small effects at the population level. Policy implications are that complementary public health strategies need to be assessed and considered to achieve growth and cognition benefits for children in helminth endemic areas.  a1943-9342, 1943-9407