02533nas a2200157 4500000000100000008004100001653001500042653001900057653000500076100001200081700001300093245020600106856026000312520178500572022001802357 2020 d10aIvermectin10aonchocerciasis10a1 aMushi V1 aKakoko D00aKNOWLEDGE, ATTITUDES, PERCEPTIONS AND ACCEPTABILITY OF ONCHOCERCIASIS CONTROL THROUGH COMMUNITY-DIRECTED TREATMENT WITH IVERMECTIN: IMPLICATIONS FOR PERSISTENT TRANSMISSION IN ULANGA DISTRICT, TANZANIA uhttps://www.researchgate.net/profile/Vivian_Mushi/publication/340686457_KNOWLEDGE_ATTITUDES_PERCEPTIONS_AND_ACCEPTABILITY_OF_ONCHOCERCIASIS_CONTROL_THROUGH_COMMUNITY-DIRECTED_TREATMENT_WITH_IVERMECTIN_IMPLICATIONS_FOR_PERSISTENT_TRANSMISSION_IN_ULANGA_DIS3 aBackground Ulanga, an onchocerciasis-endemic district in Tanzania, has received preventive chemotherapy for onchocerciasis by community-directed treatment with ivermectin (CDTI). With CDTI, interruption of transmission could occur after 14-17 years, yet transmission persists even after 20 years. This may be due to high baseline endemicity and other factors that can lower coverage of CDTI, including poor knowledge of the disease and negative attitudes and perceptions towards CDTI. This study examined community knowledge, attitudes and perceptions towards onchocerciasis control and acceptability of the CDTI program in Ulanga.

Methods
A mixed methods cross-sectional study was carried out from June to July 2018. A quantitative questionnaire was administered to 422 household members in the community. This was complemented with qualitative in-depth interviews and focus group discussions.
Results
A majority (94.1%) of community members had heard of onchocerciasis. Only 15.4% had a high level of knowledge about onchocerciasis; about half (49.2%) had a low level of knowledge on the disease and CDTI. Negative attitudes and perceptions towards CDTI prevailed in nearly half of participants (46.2% and 44%, respectively). A majority (83.4%) of respondents agreed that they will take ivermectin, and 74.4% were willing to comply with treatment for 12 to 15 years to eliminate onchocerciasis. In focus group discussions, participants reported mistrust of the method of dose calculation, that affects the acceptability and use of ivermectin treatment.
Conclusion
Inadequate levels of knowledge, negative attitudes and perceptions have the potential to affect participation in CDTI. This may result in continual transmission of onchocerciasis. a2591 – 6769