02380nas a2200181 4500000000100000008004100001260002000042653003500062653003000097100001300127700001300140700001600153700001300169700001400182245017400196856009700370520173100467 2020 d bResearch Square 10 amass drug administration (MDA) 10 aLymphatic filariasis (LF) 1 aManyeh A 1 aTobias T 1 aRamaswamy R 1 aBaiden F 1 aIbisomi L 00 aEvaluating context-specific evidence-based quality improvement intervention on lymphatic filariasis mass drug administration in Northern Ghana using the RE-AIM framework uhttps://assets.researchsquare.com/files/rs-34606/v1/18454e76-faba-47ae-a361-1adac602f3b5.pdf 3 aAbstract
BackgroundOver a decade of implementing a global strategy to eliminate lymphatic filariasis in Ghana through mass drug administration, the disease is still being transmitted in 22 districts out of an initial 98 endemic districts identified in 2000. A context-specific evidence-based quality improvement intervention was implemented in the Bole District of Northern Ghana after an initial needs assessment. This study aimed to evaluate the process and impact of the intervention on implementation of lymphatic filariasis mass drug administration in Bole District of Northern Ghana. MethodThe study used the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework based on a mixed-methods approach to evaluate the context-specific evidence-based quality improvement intervention. Results The findings of the evaluation showed that there was an improvement in social mobilization and sensitization, knowledge about LF and MDA process, willingness to ingest the medication, and adherence to the DOT Strategy. We observed a 6.3% increase in the district MDA coverage and reduction in self-reported adverse drug reaction. The level of reach, effectiveness and adoption as the district, sub-district and at the individual participants’ level suggest that the CEQI intervention is feasible to implement in LF hotspot districts based on initial context-specific needs assessment. ConclusionThe study provided the groundwork for future application of the RE-AIM framework to evaluate the implementation of context-specific evidence-based quality improvement intervention to improve LF MDAs towards the elimination of LF as a public health problem.